Oxis International Inc. - Calpain Inhibitor I

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Calpain Inhibitor I

Catalog Number: 29113

(ALLN; MG

Cell permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki=220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 0.5 nM). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. Inhibits neutral cystein proteases and proteasome (Ki = 6

**For research use only. Not for use in diagnostic procedures.**

Form:

White solid

Packaging:

25 mg

CAS:

110044

Weight:

383.5

Molecular Formula:

C₂₀H₃₇N₃O₄

Seq:

Purity:

>=98% by TLC

Solubility:

Ethanol, methanol, and DMSO

Storage:

Refrigerate. Following reconstitution, aliquot and freeze. This product is stable for 5 years as supplied. Stock solutions are stable for 6 months when frozen.

References

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MSDS:

View MSDS for Calpain Inhibitor I

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